Paproth Communication
The Whole Patient · Prologue

The Heart in the Library

A child who died some 6,500 years ago received a diagnosis in 2015 from a team of engineers, radiologists and paediatric cardiologists. In the thirteenth century a physician in Cairo who worked across many fields described how blood crosses the lungs, and European anatomists did not read his account for almost seven centuries.

Dr Michael StrupplerDr Michael Struppler
Internist and cardiologist · 3 min read

In the regional museum of Detmold, Germany, lies the mummy of a baby. Where it came from is uncertain: it is thought to be from South America. Radiocarbon dating places the child at about 4500 BCE, and the teeth suggest an age of six months at death.

In 2015 cardiologists and radiologists from the Heart and Diabetes Centre in Bad Oeynhausen passed the small body through a CT scanner and found that the left side of the heart had never grown. Hypoplastic left heart syndrome usually kills within weeks of birth, once the ductus arteriosus, a vessel that bypasses the lungs before birth, closes and the body loses its blood supply; today prostaglandins keep the duct open until a surgeon can intervene.

How this child lived for six months is unknown. The authors raised a possibility, not a finding: at high altitude the duct often closes late, and that may have bought the child time. Since the child's origin is itself uncertain, the explanation remains a guess.

Modern medicine reached that diagnosis the way it examines most patients, one competence at a time: engineers built the scanner, radiologists read it and paediatric cardiologists recognised the defect. This series follows that division of labour, mostly through the heart: who asked the questions, who could read what others had already found, and how medicine learned to ask for evidence instead of deferring to authority.

For more than a thousand years physicians followed Galen, the Greek physician of the second century, who taught that blood seeped from the right ventricle to the left through invisible pores in the septum. Avicenna's Canon of Medicine repeated the claim, and generations of commentators explained it.

Ibn al-Nafis, born in Damascus in 1213, trained at the hospital there and moved to Cairo at 23, where he became physician-in-chief of the Al-Mansouri Hospital. At 29 he wrote a commentary on the anatomy of the Canon. The septum, he stated, is solid and has no passage, visible or invisible: all the blood that reaches the left ventricle must first pass through the lungs, by small communications between the pulmonary artery and the pulmonary vein, a prediction made about 400 years before Marcello Malpighi saw the capillaries.

Where the Detmold diagnosis needed a team, Ibn al-Nafis held several fields in one head. He wrote on law, theology, philosophy and astronomy, and an early Arabic novel about a child raised alone on a desert island. The historian Nahyan Fancy has shown that commentaries like his tested each received claim by argument and at times by observation, and that his was widely cited in the Islamic world.

Europe did not read it. A Latin translation of 1547 rendered a different work of his, on compound drugs. Michael Servetus in 1552 and the anatomist Realdo Colombo in 1559 described the passage of blood through the lungs, each apparently by his own route, and many historians believe that Servetus never knew of the physician in Cairo. Neither grasped the larger circuit, which William Harvey published in 1628.

The commentary reached Western readers in 1924, when a young Egyptian physician, Muhyo al-Deen el-Tatawi, came across the manuscript in the Prussian State Library in Berlin while writing his doctoral thesis for the University of Freiburg. By then European anatomy had reached the same conclusion by other routes, more than three centuries earlier. Whether an earlier reading in Padua or Paris would have changed anything is a question the surviving record cannot answer.

Last updated: 22 October 2026

References
  1. Haas NA, Zelle M, Rosendahl W, Zink A, Preuss R, Laser KT, et al. Hypoplastic left heart in the 6500-year-old Detmold Child. Lancet. 2015;385:2432. doi:10.1016/S0140-6736(15)60770-X
  2. West JB. Ibn al-Nafis, the pulmonary circulation, and the Islamic Golden Age. J Appl Physiol. 2008;105:1877–80. doi:10.1152/japplphysiol.91171.2008
  3. Cattermole G. How Islam changed medicine: Al-Nafis, Servetus, and Colombo [letter]. BMJ. 2006;332:120. doi:10.1136/bmj.332.7533.120-c
  4. Fancy N. Verification and utility in the Arabic commentaries on the Canon of Medicine: examples from the works of Fakhr al-Dīn al-Rāzī (d. 1210) and Ibn al-Nafīs (d. 1288). J Hist Med Allied Sci. 2020;75:361–82. doi:10.1093/jhmas/jraa038
  5. Taylor J. Padua University: the role it has played in the history of medicine and cardiology and its position today. Eur Heart J. 2009;30:629–35. doi:10.1093/eurheartj/ehp082
About the author

Dr. med. Michael Struppler is a specialist in internal medicine and cardiology. He spent ten years at the Medizinische Klinik of Ludwig Maximilians University of Munich before practicing as a cardiologist in a large private practice in Munich until a few years ago. He also speaks at Continuing Medical Education events on evidence-based medicine, with a focus on the whole patient rather than the isolated organ system. He writes about the mechanisms behind cardiovascular disease and how well the evidence for treating it actually holds up.

“Ask why first. Demand the evidence second. Trust neither until both show up.”

Next week · Part 01

Long Live Aristotle

Leonardo da Vinci described diseased arteries in 1506 and showed no one. In Padua anatomists cut with their own hands and medical students had to learn mathematics, and William Harvey, who studied there, later argued for the circulation of the blood with arithmetic.

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